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can i use niacinamide with salicylic acid

‘Nicotinic acid/niacinamide’. This is because both vitamin C and glycolic acid are known to boost collagen levels in the skin and it appears that their effects may be additive. ‘Anti-melanogenic effects of resveratryl triglycolate, a novel hybrid compound derived by esterification of resveratrol with glycolic acid’. Centella Asiatica + Vitamin C + Glycolic Acid = Increased Collagen Production by 4x. Photobiol. Photochem. Use salicylic acid (psoriasis or seborrheic dermatitis) as ordered by your doctor. The addition of, Like UV radiation, visible light can also lead to the production of free radicals. Farage, M., Miller, K., Elsner, P. & Maibach, H. (2008). Some evidence suggest that this is due to its ability to increase the levels of ceramides, free fatty acids, and cholesterol in the stratum corneum [52]. Salicylic Acid + Niacinamide "Salicylic Acid is a pore-cleansing Beta Hydroxy Acid (BHA). Both have anti-aging and anti-acne effects and offer some level of UV protection [1][2]. But, just like retinol, it can be drying to skin. Sound simple enough, right? In fact, a large randomized controlled study found that the combination of niacinamide and NAG worked really well at reducing pigmentation. ‘The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations in stimulating collagen and fibronectin synthesis in cultured human skin fibroblast’. Lol. Combining niacinimadie’s oil-reducing prowess with salicylic acid’s ability to dissolve excess oil is a great way to help keep pores clear and breakouts at bay. Can You Use Glycolic Acid and Retinol Together? (2005). AHAs, such as glycolic and lactic acid, act as chemical exfoliants and help remove dead skin cells and loosen the top layer of skin. ‘The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer’. ‘Hydration effects on the barrier function of stratum corneum lipids: Raman analysis of ceramides 2, III and 5’. Although, resveratrol, alone, performed similarly well to the combination, Dr Dennis Gross Alpha Beta Universal Daily Peel, Retinol is a derivative of vitamin A that can increase the rate of, However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL), Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration, Some evidence suggest that this is due to its ability to increase the levels of ceramides, free fatty acids, and cholesterol in the stratum corneum. In addition, vitamin C is one of the few examples in life where three is not a crowd. ‘Characteristics of the aging skin’. Marczyk, B., Mucha, P., Budzisz, E., Rotsztein, H. (2014). Glycolic Acid + Vitamin C = Increased Collagen and Skin Thickness, Reduced Hyperpigmentation. These come up especially around my time of the month and whenever I use a wrong product (hello, over-sensitive skin!). This basically means that niacinamide prevents pigment leaking into other surrounding cells. ‘Caffeine’s mechanisms of action and its cosmetic use’. Whenever I feel breakouts coming up, so mostly right before and after my period and whenever I have a bad reaction to a product. Can You Use Vitamin C and Retinol Together? The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. ‘Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients’. Hughes, M., Williams, G., Baker, P., Green, A. With its offer of retinoids, direct acids, oils and more straightforward products, The Ordinary is known to be a very humble and no-nonsense brand. thanks alot, this really help me to choose and mix my skincare routine. You can use niacinamide in the morning and salicylic acid followed by … Its effects are thought to be largely due to various, A number of studies that have investigated the wound-healing benefits of centella asiatica have found that topical application of the extract increases the production of collagen, Another antioxidant skincare ingredient that promotes wound-healing and boosts collagen production is vitamin C. For this reason, the combination of vitamin C and centella asiatica may lead to improved anti-oxidant, collagen-boosting, and wound-healing effects. ‘Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine’. Song, X., Xu, A., Pan, W. et al. Usuki, A., Ohashi, A., Sato, H., Ochiai, Y., Ichihashi, M. & Funasaka, Y. When used together, vitamin C and glycolic acid demonstrated an ability to significantly improve hyperpigmentation, as well as reduce pore size and improve skin texture [54]. (2003). In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with both vitamin E and ferulic acid! Use on your skin only. The ordinary niacinamide worked brilliantly for me. While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. Also to know i can mix Gycolic Acid with Vitamin C. Yeah! Alternatively, the new active might have been the tipping point, pushing your skin into a state of irritation. This basically means that niacinamide prevents pigment leaking into other surrounding cells. Bissett, D., Robinson, L., Raleigh, P. et al. The Ordinary! Man, M., Feingold, K. & Elias, P. (1993). Glycolic acid, alone, boosted collagen production 2-fold (2x), 3-fold (3x) when combined with centella asiatica, and four-fold (4x) when combined with both vitamin C, Centella Asiatica + Vitamin A + Vitamin C + Vitamin E = 3x, Centella Asiatica + Vitamin C + Glycolic Acid = 4x, Zinc oxide is a mineral (physical/inorganic) sunscreen, which means that it protects the skin from UVA and UVB radiation by reflecting and scattering light. (2006). You can find The Ordinary in Belgium on ASOS or the British website Cult Beauty (but they’re very often sold out!). Because NAG and niacinamide target pigmentation in two separate ways (NAG prevents melanin production while niacinamide prevents the spread of existing melanin), they are highly likely to compliment each other when used together. With thousands of different skincare products available, we’re often spoilt for choice. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67% [39]. You can also not use the Niacinamide together with any Vitamin C product, because it would affect both their effectivity, but of course there’s nothing The Ordinary can do about that :). Scientific research studies are here to help us out! ‘Optimization of physiological lipid mixtures for barrier repair’. Herman, A. Add these two ingredients when cleansing your face and they will flow away directly with the water. Considering the price, it is probably best to save this product just for the dark spots that rea ‘Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety’. Vitamin C is the most abundant antioxidant in the skin and is essential for the production of collagen [16]. Davies, M. & Marks, R. (1976). When i googled ethyl ascorbic acid ph level it said 4.0-5.0 so i just dont understand why i cant use ethyl ascorbic acid and buffet together. Hashim, P. (2014). ‘Sunscreens inadequately protect against ultraviolet-A-induced free radicals in skin: implications for skin aging and melanoma?’. Recently, a hybrid of glycolic acid and resveratrol, resveratryl triglycolate, has demonstrated the ability to reduce sun induced pigmentation when applied twice daily for 6-8 weeks [48]. N-Acetyl Glucosamine (NAG) is an amino sugar and precursor to hyaluronic acid that inhibits tyrosinase glycosylation, thus reducing melanin production [61]. Therefore, it was recommended that in order to achieve optimal results from both ingredients, the two should be used separately. I also wanted to add in a bha product, so I purchased Paula's Choice 1% salicylic acid liquid exfoliant. ‘The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells’. TULA Clear It Up Acne Clearing + Tone Correcting Gel: A two percent salicylic acid gel, with niacinamide halfway down the ingredients list. Just use them at different times. Sincerely. ‘Sunscreen and Prevention of Skin Aging: A Randomized Trial’. For this reason, the combination of vitamin C and centella asiatica may lead to improved anti-oxidant, collagen-boosting, and wound-healing effects. AHAs, such as glycolic and lactic acid, act as chemical exfoliants and help remove dead skin cells and loosen the top layer of skin. Milstone, L. (2004). Niacinamide 10% + Zinc 1% Salicylic Acid 2% Solution Anhydrous Solutions = 2 Add number 2 to all these products if you have them. In one study, pre-treatment of the skin with niacinamide provided additional barrier protection and made the skin more tolerant of retinoic acid (a prescription strength version of retinol) [50]. When this lipid matrix is depleted, skin can become dehydrated [25] which results in rougher and duller looking skin. Since alpha and beta hydroxy acids are usually acidic, the application creates the perfect environment on your skin for vitamin C. Furthermore, the retinaldehyde and glycolic acid formulation can enhance the effects of these other acne treatments [60]. <3 Kameyama, K., Sakai, C., Kondoh, S. et al. ‘Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity’. In one study, pre-treatment of the skin with niacinamide provided additional barrier protection and made the skin more tolerant of retinoic acid (a prescription strength version of retinol). All content, including, but not limited to, text, images, links, and other material does not constitute medical or other professional advice, and is not intended to be a substitute for professional medical advice. I always thought that Retinol and AHA could NOT be used together??? I use the Niacinamide + Zinc first, all over my face (except for my nose, eyes and mouth area!) Still, if both ur niacinamide and Vit C (LAA) are in 2 different products, then just separate the order and use one in AM/PM lah. & Brody, N. (2011). While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements [42]. Golden, G., Guzek, D., Kennedy, A., McKie, J. It started about a year ago. For example, glycolic acid can significantly improve the resolution of the comedones, papules, and pustules commonly experienced with acne [57]. They have very specific products for any skin type and any concern, at a very low price rate. & Herman, A. As the stratum corneum is the first to absorb the oxidative stress from free radicals produced by UV radiation, the levels of vitamin E in the skin are often depleted and regular topical application of vitamin E is recommended [18]. Both ingredients target both of these causes and research has found that topical combinations of salicylic acid and niacinamide can significantly reduce surface sebum levels and pore size after 12 weeks of use, InstaNatural Age Defying Skin Clearing Moisturizer, This is because roughly 80-90% of all facial skin aging is caused by sun damage, This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin, In addition, free radicals are also produced by other forms of solar radiation, including visible light and infrared radiation. ‘Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance’. For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use [58]. ‘Efficacy and safety of 0.1% retinaldehyde/ 6% glycolic acid (Diacneal) for mild to moderate acne vulgaris’. Yes, you can pair both of these ingredients together. Salicylic acid can improve the signs of premature skin aging by increasing collagen levels, improving the quality of elastic fibers, and shrinking pores for a smoother complexion [3]. Ceramides + Cholesterol + Free Fatty Acids = Increased Skin Hydration. 82, 1123– 1131. Products That Combine Green Tea & Caffeine: Our skin’s hydration generally depends on two major factors; the presence of natural moisturising factors and the structure and composition of the lipids in the stratum corneum. Some research suggests that iron oxide can increase the overall sun protection offered by zinc oxide sunscreens by absorbing all wavelengths of visible light [40]. Some research suggests that glycolic acid, as well as other AHAs, also inhibit tyrosinase [45]. Another antioxidant skincare ingredient that promotes wound-healing and boosts collagen production is vitamin C [19]. For example, 2% NAG, alone, reduced the appearance of facial hyperpigmentation, but this reduction was far greater when 2% NAG was combined with 4% niacinamide [61]. Acne Scars vs Acne Marks | A Guide To The Different Causes & Treatment Options. Salicylic acid could dry your skin and cause flakiness, tightness, and itchiness if you don’t moisturize your skin enough. Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration [51]. But we’re already using the last skincare ingredient that they recommended and it has become our new holy grail product. 82, 1123– 1131. Battie, C., Jitsukawa, S., Bernerd, F., Del Bino, S., Marionnet, C. & Verschoore, M. (2014). But are some sunscreen ingredient combinations better than others? This means that combining the two can have an additive effect. Telang, P. (2013). that is known to reduce pigmentation and inflammation and has anti-aging properties, It inhibits tyrosinase, the key enzyme in the production of melanin, in various ways and thus prevents the conversion of DOPA to melanin, Some research suggests that glycolic acid, as well as other AHAs, also inhibit tyrosinase, In addition, AHAs increase the rate of skin cell turnover which helps bring skin pigment to the surface of the skin faster where it can be shed as part of normal epidermal desquamation (skin shedding), In addition, glycolic acid is very good at penetrating skin, Recently, a hybrid of glycolic acid and resveratrol, resveratryl triglycolate, has demonstrated the ability to reduce sun induced pigmentation when applied twice daily for 6-8 weeks, When investigated separately, this combination of resveratrol and glycolic acid inhibited tyrosinase more effectively than glycolic acid alone. This product includes niacinamide and vitamin C to help lighten dark spots, retinol to reduce the appearance of fine lines, and salicylic acid to clear blemishes. Iron oxide is not an approved sunscreen but is often added to mineral sunscreens to reduce white cast. In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application [31]. ‘Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin’. Ex. Will they interact and leave us with irritated and painful skin? Niacinamide & Salicylic Acid Niacinamide, a water soluble form of vitamin B3, and salicylic acid, a beta-hydroxy acid, work particularly well when combined together. Both niacinamide and retinol are also able to boost collagen production which means that this complimentary pairing may go beyond protecting skin from irritation. Products That Combine Vitamin C & Vitamin E & Ferulic Acid: Another great antioxidant pairing is green tea and caffeine. Wang, C., Huang, C., Hu, C. & Chan, H. (1997). Barbara. Dreno, B., Nocera, T., Verriere, F. et al. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration, Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier, A complete mixture of all three substances needs to be applied in order to repair the skin’s barrier function and, In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application, However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids), with ceramide-dominant formulations being more suitable for some skin conditions, Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x) [19][20]. When used together, start by applying hyaluronic acid then followed by niacinamide. Read More. When investigated separately, this combination of resveratrol and glycolic acid inhibited tyrosinase more effectively than glycolic acid alone. How To Make Your Face Smooth (According To 20+ Research Studies), 12 Combinations Of Skincare Ingredients That Work Better Together, Vitamin C & Vitamin E (& Bonus Ferulic Acid), Centella Asiatica & Vitamin C (& Bonus Glycolic Acid), A Summary Of The Skincare Ingredients That Work Well Together. 2 Common Myths Busted! Visible light, especially high energy visible (HEV) light, represents about 39-44% of total solar radiation and enters the skin in the same way that UV radiation does [38]. ‘Practical uses of botanicals in skin care’. ‘Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes’. For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use, The same combination has also demonstrated effectiveness at preventing and healing the post-inflammatory hyperpigmentation (PIH) associated with acne, Research also demonstrates that this formulation can also be used along-side benzyl peroxide and topical antibiotics without causing irritation. Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. Gehring, W. (2004). ‘Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier’. Bonus tips: Drink lots of water. ‘Treatments Improving Skin Barrier Function’. Niacinamide (Vitamin B3) reduces visible congestion and blemishes, zinc balances the production of sebum (your skin’s oil). These two definitely address a certain skin type: the Niacinamide + Zinc is your best friend if you suffer from oily skin, and combined with the the Salicylic Acid it’s perfect to treat blemish- and acne-prone skin. Infrared radiation accounts for about 53% and visible light accounts for about 39-44% of total solar radiation [11]. ‘Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin’. Niacinamide reduces sebum production by decreasing the glyceride and fatty acids of surface sebum which helps to reduce pore size and improve skin texture [2]. Haywood, R. (2006) Relevance of sunscreen application method, visible light and sunlight intensity to free-radical protection: A study of ex vivo human skin. Vitamin C + Vitamin E + Ferulic Acid = Increased Effect Of Vitamin C By 8x. Basically, the addition of vitamins A, C, and E with centella asiatica didn’t increase the production of collagen anymore than when vitamin C was added to centella asiatica on its own. Lol. Niacinamide and salicylic acid work together to calm and minimize breakouts, while licorice root extract and vitamin C help the niacinamide brighten hyperpigmentation and acne scars. It’s how they keep the price so low, but it also counteracts with makeup and sometimes with other products. Other research has found that this is an additive effect. Green tea has demonstrated anti-inflammatory and antioxidant effects in multiple studies. Kaye, E., Levin, J., Blank, I. et al. ‘Comparison of topical therapy for striae alba (20% glycolic acid/ 0.05% tretinoin versus 20% glycolic acid/ 10% L-ascorbic acid)’. ‘Studies on the effect of salicylic acid on normal skin’. Frankly, I have never suffered from severe acne, but based on the stories I’ve heard it should work quite well on that too! This multi-functional niacinamide serum is a perfect solution for those dealing with both acne and its aftermath. In fact, it can actually stop the visible signs of skin aging when used correctly [7]. In fact, a large randomized controlled study found that the combination of niacinamide and NAG worked really well at reducing pigmentation. From left to right: Niacinamide +Zinc, High Spreadability Fluid Primer, Salicylic Acid 2%, Buffet, Azelaic Acid Suspension 10% Now the first one I'm gonna discuss is the Azelaic Acid. Or maybe, just maybe, will they enhance each other and let us experience the glowing skin that we have only ever dreamed of? Green Tea + Caffeine = Increased Protection Against UVB-induced Skin Cancer. You can use a serum or moisturizer to rebalance your skin. Loden, M. (2016). Other ingredient combinations to check out: Have you found any skincare ingredient combinations that work particularly well? However, in certain formulas, the combination of glycolic acid and retinol can be well-tolerated and a complimentary and effective acne treatment. I’m not sure why you’re using alpha arbutin as that’s a spot treatment for dark spots. Salicylic acid or benzoyl peroxide must be absorbed by the skin to be effective. Notify me of follow-up comments by email. ‘Intrinsic and extrinsic factors in skin ageing: a review’. Ezra, if you have oily, acne-prone skin stop using a AHA exfoliator and switch to salicylic acid. Although the natural compounds in willow bark have provided people relief from pain and fever for centuries, modern-day salicylic acid is biosynthesized, or created artificially. Retinol + Niacinamide = Increased Tolerability Of Retinol. ‘Complimentary antioxidant function of caffeine and green tea polyphenols in normal human skin fibroblasts’. Castanedo-Cazares, J., Hernandez-Blanco, D., Carlos-Ortega, B., Fuentes-Ahumada, C. & Torres-Alvarez, B. We have already seen earlier how vitamin C and glycolic acid enhanced each others collagen-boosting effects when combined with centella asiatica [35]. Niacinamide + Salicylic Acid = Reduced Pore Size, Reduced Sebum Production. ‘After 30 years…the future of hydroxyacids’. by neutralizing the free radicals that are produced upon exposure to these toxins [14]. This is because roughly 80-90% of all facial skin aging is caused by sun damage [8]. Other research has found that glycolic acid and vitamin C combinations are particularly good at treating stretch marks by increasing epidermal and papillary dermal thickness [55]. Salicylic acid can improve the signs of premature skin aging by increasing collagen levels, improving the quality of elastic fibers, and shrinking pores for a smoother complexion, as well as reducing redness and pigmentation and improving skin barrier function, As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle, This also means that salicylic acid can access sebaceous glands and reduce sebum production, Niacinamide reduces sebum production by decreasing the glyceride and fatty acids of surface sebum which helps to, Enlarged pores are caused by two main factors; increased sebum levels and reduced levels of collagen and elasticity in the skin. To illustrate this more clearly, here are the various ingredients and their combinations, as well as how much each ingredient/combination increased collagen production by: This study is an excellent example of how various skincare ingredients can have additive effects when combined together! Sometimes, more is better! We have already seen earlier how vitamin C and glycolic acid enhanced each others collagen-boosting effects when combined with centella asiatica. Hakozaki, T., Minwalla, L., Zhuang, J. et al. Like salacin, salicylic acid is an anti-inflammatory substance with chemical similarities to aspirin. Berson, D., Osborne, R., Oblong, J., Hakozaki, T., Jonson, M. & Bissett, D. (2014). Available at: Oresajo, C., Pillai, S., Manco, M., Yatskayer, M. & McDaniel D. (2012). N-Acetyl Glucosamine + Niacinamide = Reduced Pigmentation. All their products are cruelty-free and are not sold in China. Frederick, J., Snell, H. & Haywood, E. (1989) ‘Solar ultraviolet radiation at the earth’s surface’. Laura is currently working in healthcare education and writes for ScienceBecomesHer in her spare time. This suggests that application of niacinamide is able to prevent the typical irritant effects often experienced upon commencing retinol treatment. Williams, M. & Elias, P. (1987). ‘New insights in photoaging, UVA induced damage and skin types’. Retinol also helps to improve acne by increasing the rate of skin cell turnover and renewal which means that dead skin cells are shed quicker [49]. Specifically, 4% niacinamide combined with 2% NAG was significantly more effective at reducing pigmentation than a vehicle control formulation, Furthermore, niacinamide appears to have an additive effect when combined with NAG. Similar levels of free radical protection are also offered when antioxidants are used alone [15]. Products That Combine Glycolic Acid & Resveratrol: Retinol is a derivative of vitamin A that can increase the rate of skin cell turnover and renewal, reduce sun damage, boost collagen production, improve the appearance of wrinkles, reduce pigmentation, and increase skin hydration [49]. (What Is Skin pH?). Do not take salicylic acid (psoriasis or seborrheic dermatitis) by mouth. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. According to Elle magazine, dermatologist Jenny Kim says that while salicylic acid works to kill pimple-causing bacteria, retinol removes the upper layers of skin to get rid of pimples … Parameshwaraiah, S. & Shivakumar, H. (1998). Because of its ability to reduce inflammation, decongest pores and assist with exfoliation, it is commonly used to treat acne," McBride explains. (2018). A number of in vitro and in vivo studies have demonstrated that these lipids, particularly ceramides play a vital role in skin hydration by regulating the amount of water in and out of the skin [26][27]. It also means you have to limit your sun exposure and wear SPF, as the use of BHA makes you more sensitive to the sun. Hello! When using hyaluronic acid and retinol, apply retinol first, then hyaluronic acid. Research suggests that niacinamide can decrease the transfer of melanosomes from melanocytes to keratinocytes by up to 68% and interferes with the cell signalling pathways between keratinocytes and melanocytes [63]. Posted 12:27 am by & filed under .-sunscreen With antioxidants like vitamin C and E working in tandem to undo the damage caused by UV rays, you’re probably thinking how it makes One study found that a topical combination of vitamin C and a centella asiatica extract significantly improved skin suppleness, firmness, and hydration, as well as improving the appearance of wrinkles, after 6 weeks of use, Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. Less spots, slightly mire refined pores, over all improved texture. I would however not use them when my skin is dehydrated or sensitive, especially not the direct acid. ‘Near visible light and UV photoprotection in the treatment of melasma: a double-blind randomized trial’. Can you tell i love Vit C? The Ordinary Niacinamide 10% + Zinc 1% is a high-strength potion of vitamins and minerals. Stallings, A. This suggests that application of niacinamide is able to prevent the typical irritant effects often experienced upon commencing retinol treatment. But with so many acids on the market, it can seem overwhelming to remember which to use and for what and which products to buy. Photobiol. Thank you again. In addition, AHAs increase the rate of skin cell turnover which helps bring skin pigment to the surface of the skin faster where it can be shed as part of normal epidermal desquamation (skin shedding) [46]. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration [28]. Keep out of your mouth, nose, and eyes (may burn). which results in rougher and duller looking skin. However, initially, retinol can cause irritation and dryness of the skin by damaging the skins barrier and increasing transepidermal water loss (TEWL) [50]. ‘Irradiation of skin with visible light induced reactive oxygen species and matrix degrading enzymes’. However, NAG can be unstable when used alone [62]. As you can imagine, the two combined may be quite irritating for skin. ‘Vitamin E in dermatology’. For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C [17]. (2010). In fact, with some formulations it does appear that more is more! (This happened to me, when I went from Biologique Recherche Lotion P50, which contains lactic acid, to COSRX BHA Blackhead Power Liquid, which contains salicylic acid—a much stronger acid.) Jagdeo, J. Niacinamide offers similar benefits [4], as well as reducing redness and pigmentation and improving skin barrier function [2]. Unfortunately, sunscreen is only able to block about 55% of the free radicals produced by UV exposure [12] and, alone, provides no protection from the free radicals produced by either infrared radiation or visible light [13]. Hello youthful skin! Sunscreen + Antioxidants = Increased Photoprotection. However, in certain formulas, the combination of glycolic acid and retinol can be well-tolerated and a complimentary and effective acne treatment. This also means that salicylic acid can access sebaceous glands and reduce sebum production [6]. This makes it a perfect spot treatment while it also improves your skin’s clarity. Green, B. They basically ‘mop-up’ the damage done by UV radiation and other environmental aging factors (smoking, pollution, etc.) (2010). (2008). & Lim, H. (2008). ‘Effects of Visible Light on the Skin’. While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. As you can imagine, the two combined may be quite irritating for skin. & De Ponti, I. ‘Pharmacological review on centella asiatica: A potential herbal cure-all’. Caffeine has also demonstrated antioxidant and photoprotective effects and offers additional UV radiation and free radical protection when added to sunscreens, As caffeine is present in green tea, both ingredients naturally complement each other’s effects, Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer, In addition, the two antioxidants in combination have demonstrated the ability to improve the appearance of acne, Neostrata Restore Redness Neutralizing Serum, The structure and composition of the lipids in the stratum corneum is often referred to as the lipid matrix and creates a barrier function via its mixture of ceramides, cholesterol, and free fatty acids. Both ingredients target both of these causes and research has found that topical combinations of salicylic acid and niacinamide can significantly reduce surface sebum levels and pore size after 12 weeks of use [2]. Vitamin E is the most important lipid-soluble antioxidant in tissue and is particularly abundant in the outermost layer of the skin (the stratum corneum) where it is delivered by sebum. The fact that I no longer had an easy skin type was both a physical and a mental problem for me and it inspired me even more to read into skin care and get to the bottom of the problem. I used to live their Salicylic acid but developed a bit of a sensitivity so now only the face mask. Photochem. Resveratrol + Glycolic Acid = Reduced Hyperpigmentation. In fact, the anti-aging effects of vitamin C are enhanced even further when it is combined with, Timeless Skincare 20% Vitamin C, E, & Ferulic Acid Serum, SeoulCeuticals Day Glow Serum 20% Vitamin C, E, & Ferulic Acid Serum With Hyaluronic Acid. This is because both vitamin C and glycolic acid are known to boost collagen levels in the skin and it appears that their effects may be additive. Infrared radiation accounts for about 53% and, Unfortunately, sunscreen is only able to block about 55% of the free radicals produced by UV exposure, and, alone, provides no protection from the free radicals produced by either infrared radiation or visible light, When added to sunscreen, antioxidants are able to reduce the production of free radicals by up to 78%. This is a great example of how a number of ingredients that when combined together, in theory, should be highly irritating to the skin. Their Azelaic acid actually formed spots - the formula/texture if it doesn’t shut my skin. I did learn alot from reading your article. Deciem Responses Regarding Conflicts & The Ordinary Products You Can & Cannot Mix Why can´t I now use Vitamin C derivatives with Niacinamide? Great for acne breakouts, salicylic acid shrinks them up, and fast. Tfayli, A., Jamal, D., Vyumvuhore, R., Manfait, M. & Baillet-Guffroy, A. Both have anti-aging and anti-acne effects and offer some level of UV protection. We read a news article that suggests that ingredient X is the next best skincare saviour. (2016). Jo, D., Seok, J., Kim, S. et al. Mahmoud, B., Hexsel, C., Hamzavi, I. Theyre the miracle tools used to fight acne, wrinkles, age spots, scarring, and uneven skin tone. Vitamin C and vitamin E are possibly the best example of a skincare power couple as they each enhance the effects of the other. Your email address will not be published. In addition, free radicals are also produced by other forms of solar radiation, including visible light and infrared radiation. Same as AM but without SPF Niacinamide can help decrease retinol irritation, and on top of that, the added barrier function benefit definitely is a plus! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047947/, https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118384824.ch10, https://www.ncbi.nlm.nih.gov/pubmed/17134422, https://doi.org/10.1111/j.1524-4725.2005.31732, https://www.ncbi.nlm.nih.gov/pubmed/952756/, https://www.ncbi.nlm.nih.gov/pubmed/24641601/, https://www.ncbi.nlm.nih.gov/pubmed/23732711, https://www.ncbi.nlm.nih.gov/pubmed/18377617, https://www.researchgate.net/publication/256618684_Free_Radicals_In_Biology_And_Medicine, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-1097.1989.tb05548.x, https://www.ncbi.nlm.nih.gov/pubmed/14632206, https://www.ncbi.nlm.nih.gov/pubmed/17205635, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1529-8019.2012.01505.x, https://www.sciencedirect.com/science/article/pii/S0022202X15358292, https://www.sciencedirect.com/science/article/pii/S0738081X09001254, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605218/#B3, https://www.ncbi.nlm.nih.gov/pubmed/18045356/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673383/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976416/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958188/, https://www.ncbi.nlm.nih.gov/pubmed/23075568, https://europepmc.org/abstract/med/21720657, https://www.jaad.org/article/S0190-9622(17)31504-9/fulltext, https://www.ncbi.nlm.nih.gov/pubmed/23951566, https://pubs.acs.org/doi/abs/10.1021/bi00382a045?journalCode=bichaw, https://core.ac.uk/download/pdf/82665629.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216025/, https://www.jaad.org/article/S0190-9622(02)00048-8/fulltext, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116297/, https://www.ncbi.nlm.nih.gov/pubmed/9731470/, https://www.researchgate.net/profile/Puziah_Hashim4/publication/260431233_The_effect_of_Centella_asiatica_vitamins_glycolic_acid_and_their_mixtures_preparations_in_stimulating_collagen_and_fibronectin_synthesis_in_cultured_human_skin_fibroblast/links/564aaf6208ae44e7a28dd030.pdf, https://www.ncbi.nlm.nih.gov/pubmed/18503551/, https://www.ncbi.nlm.nih.gov/pubmed/16311163, https://jamanetwork.com/journals/jamadermatology/article-abstract/552806, https://www.ncbi.nlm.nih.gov/pubmed/18248499, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936427/, https://www.ncbi.nlm.nih.gov/pubmed/21348540?dopt=Abstract, https://www.ncbi.nlm.nih.gov/pubmed/14756523/, https://www.sciencedirect.com/science/article/pii/S0923181104000982, https://link.springer.com/article/10.1007/s00403-016-1644-9, https://www.ncbi.nlm.nih.gov/pubmed/29663438, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/, https://www.spandidos-publications.com/ijmm/22/2/229, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1473-2130.2004.00115, https://www.ncbi.nlm.nih.gov/pubmed/8543691/, https://www.tandfonline.com/doi/abs/10.3109/14764172.2012.748199, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.1998.tb04262.x, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/, https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.1997.tb00003.x, https://www.karger.com/Article/Abstract/81498, https://www.karger.com/Article/Abstract/81500, https://www.ncbi.nlm.nih.gov/pubmed/17348991, https://www.ncbi.nlm.nih.gov/pubmed/20725554?dopt=Abstract, https://www.ncbi.nlm.nih.gov/pubmed/12100180, https://www.ncbi.nlm.nih.gov/pubmed/19845667/. I was so confused. Hydroxy acids are particularly useful for treating, For example, glycolic acid can significantly improve the resolution of the comedones, papules, and pustules commonly experienced with acne, Retinol also helps to improve acne by increasing the rate of skin cell turnover and renewal which means that dead skin cells are shed quicker. Glycolic acid, alone, boosted collagen production 2-fold (2x), 3-fold (3x) when combined with centella asiatica, and four-fold (4x) when combined with both vitamin C andcentella asiatica [35]. Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier [29]. In fact, a number of different skincare ingredients compliment and enhance the effects of others. Because they both tackle the same issues and I feel like they work best when teamed up, I decided to combine the two products into one review. Together, the duo keeps skin in tact and less apt to become sensitive. Although, resveratrol, alone, performed similarly well to the combination [47]. Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production [53][45]. Similar levels of free radical protection are also offered when antioxidants are used alone, Replenix Antioxidant Sunscreen Moisturizer, Murad City Skin Age Defense Broad Spectrum SPF 50 PA++++, La Roche-Posay Anthelios Melt-In Sunscreen Milk SPF 60, Heliocare 360º Gel Oil-Free SPF 50 Sunscreen, However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. When added to sunscreen, antioxidants are able to reduce the production of free radicals by up to 78%. Follow all instructions closely. Sparavigna, A., Tenconi, B. I prefer using these in the evening, as the formula of both doesn’t do very well under makeup. ‘Topical vitamin C and the skin: mechanisms of action and clinical applications’. ), especially in relation to the effect, The packaging is really simple and practical, no-nonsense, The formula, as I said, is not ideal. Here are 12 combinations of skincare ingredients that work better together! The name's pretty new too me. I am planning on writing a full blogpost on skin care acids, so stay tuned if you want to know more about that. Another great skincare ingredient combination for hyperpigmentation and melasma is glycolic acid and resveratrol. The Importance Of Sunscreen: Scientific Sunscreen Guide Part I. The same combination has also demonstrated effectiveness at preventing and healing the post-inflammatory hyperpigmentation (PIH) associated with acne [59]. The major polyphenol present in green tea is epigallocatechin-3-gallate (EGCG) that has also been shown to have sunscreen properties [21]. “However, like aspirin, salicylic acid also has anti-inflammatory properties which can calm the skin and minimize irritation.” Many labels for acid-based products display the percentage of acid used (i.e., 2 percent salicylic acid), informing consumers of a product’s supposed strength. I haven't used any product wi Then use The ordinary niacinamide 10% & zinc 1% for oil control you want. ‘Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats’. (2016). Siu, S., Ferzili, G. & Brody, N. (2017). Available at: https://www.ncbi.nlm.nih.gov/pubmed/17205635. This website is intended for informational and/or educational purposes only. Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both together may help prevent free radical production and UVB-induced skin cancer [23]. Read all information given to you. As you can see, niacinamide and salicylic acid offer similar benefits but work in slightly different ways. For this reason, antioxidants and sunscreens make a perfect pairing and are much more effective when used together. In fact, vitamin C is the best-known stimulator of collagen production [35]. Its effects are thought to be largely due to various saponins contained within centella asiatica extracts [33]. & Potts, R. (1986). Ash, K., Lord, J., Zukowskl, M. & McDaniel, D. (2013). Ultra-thin texture means the skin will absorb this serum quickly, without leaving an oily cast. Bissett, D., Oblong, J. ‘An overview of ultraviolet radiation, sunscreens, and photo-induced dermatoses’, Haywood, R. (2006) Relevance of sunscreen application method, visible light and sunlight intensity to free-radical protection: A study of ex vivo human skin. I like how my skin looks after using for a few days! Today, I finally feel as if I have it under control thanks to lots of patience, a dietary turnover and these two products by The Ordinary: the Niacinamide 10% + Zinc 1% and the Salicylic Acid 2% Solution. The Problem with Mixing Niacinamide and Acid Together Resveratrol is the potent antioxidant found in grapes (and red wine!) What Does pH Balanced Mean? That’s right, there truly are some skincare ingredient power couples! If your makes your skin itchy, don’t use it all. However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. Ingredients. Frankly, I have never suffered from severe acne, but based on … ‘Stratum corneum lipid phase transitions and water barrier properties’. 5 Of The Best Hydrating Products For Acne Prone Skin. One study found that a topical combination of vitamin C and a centella asiatica extract significantly improved skin suppleness, firmness, and hydration, as well as improving the appearance of wrinkles, after 6 weeks of use [36]. Another great antioxidant pairing is green tea and caffeine. As caffeine is present in green tea, both ingredients naturally complement each other’s effects [23]. Derma E Acne Blemish Control Treatment Serum: A gentle 0.5 percent salicylic acid serum, with niacinamide around the middle of the ingredients list. It contains 2% of salicylic acid that works effectively on my skin. In order to get the maximum benefits from our skincare ingredients, we should look for products that contain the above combinations. Burke, K. (2007). According to Maiman, the combination of azelaic acid, niacinamide and salicylic acid are “generally considered safe for both pregnant and lactating … ‘Chapter 10: Niacinamide: A topical vitamin with wide-ranging skin appearance benefits’. This is particularly relevant for individuals with hyperpigmentation and melasma as visible light can increase melanin production [41]. In this way, you can replenish your skin with plenty of hydration first. (2002). For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C, Vitamin E is the most important lipid-soluble antioxidant in tissue and is particularly abundant in the outermost layer of the skin (the stratum corneum) where it is delivered by sebum. Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production, When used together, vitamin C and glycolic acid demonstrated an ability to significantly improve hyperpigmentation, as well as reduce pore size and improve, Other research has found that glycolic acid and vitamin C combinations are particularly good at treating stretch marks by increasing epidermal and papillary dermal thickness, This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent, Another skincare ingredient combination that is often shunned due to its irritation potential is that of retinol and alpha-hydroxy acids (AHAs). ... (BHAs) like salicylic acid can be used first to “prep” the skin. But, that doesn’t mean these two can’t be part of your anti-acne routine, as well. (2005). Related Reading: Niacinamide & Retinol Together = A Perfect Pair! I have both of these products from The Ordinary. Poli, F., Ribet, V., Lauze, C., Adhoute, H. & Morinet, P. (2005). Zinc oxide is a mineral (physical/inorganic) sunscreen, which means that it protects the skin from UVA and UVB radiation by reflecting and scattering light. If you’re looking for some hormonal breakout warriors, read on! Antioxidants are molecules that naturally co-exist in our skin to protect it from free radical damage. Chamlin, S., Kao, J., Frieden, I. et al. As it’s so harsh on its own, it’s not a good idea to use it together with salicylic acid or retinoids. As salicylic acid is oil-soluble, it easily penetrates pores in order to unclog them by loosening and detaching the skin cells and debris that build up within the hair follicle [5]. Park, S., Seok, J., Kwak, J. et al. In addition, the two antioxidants in combination have demonstrated the ability to improve the appearance of acne [24]. (2013). Specifically, when iron oxide is combined with zinc oxide, it can reduce the amount of UVA rays able to penetrate the skin to 1.5% [37]. Specifically, 4% niacinamide combined with 2% NAG was significantly more effective at reducing pigmentation than a vehicle control formulation [64]. Kornhauser, A., Coelho, S. & Hearing, V. (2010). & Gajjar, A. Keen, M. & Hassan, I. Post Inflammatory Erythema: 12 Effective Treatment Options. However, the above research proves that this is not necessarily the case. That does seem like alot. Kimball, A., Kaczvinsky, J., Li, J., Robinson, L. et al. Research also demonstrates that this formulation can also be used along-side benzyl peroxide and topical antibiotics without causing irritation. Liebel, F., Kaur, S., Ruvolo, E., Kollias, N. & Southall, M. (2012). I have long accepted that my skin will never be free from blemishes and oil-overproduction. (2002). Specifically, a mix of 0.5% ferulic acid and 1% vitamin E with 15% vitamin C increases the effects of vitamin C eight-fold (8x) [19]. The greasy T-zone had always been there, but the under-skin bumps on my forehead and red, spotty patches were new. (2014). ‘RALGA (Diacneal), a retinaldehyde and glycolic acid association and post-inflammatory hyperpigmentation in acne – a review’. Mao-Qiang, M., Feingold, K., Thornfeldt, C. & Elias, P. (1996). ‘Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in guinea pig skin’. If you’ve ever wondered whether you can incorporate niacinamide and acid in one skincare routine, rest assured—you definitely can! The addition of iron oxide to sunscreens also happens to broaden the UV protection of mineral sunscreen agents into the longer UVA and visible light spectrums. ‘Human skin-depigmenting effects of resveratryl triglycolate, a hybrid compound of resveratrol and glycolic acid’. Gycolic toner, pure L Absorbic Acid powder mix with a snail mucin and a Vit C serum (Andalou) with a Vit C E Ferulic oil?? Salicylic acid and retinol are medications that can help clear acne. Thanks so much!! (2013). Related Reading: Does Niacinamide Cause Purging? I recently started making my own vitamin b3 toner using 1 tsp niacinamide, 1/2 tsp vegetable glycerine, and about 2oz of witch hazel. Products That Combine Ceramides & Cholesterol & Fatty Acids: Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. But, there’s a catch. This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin [9][10]. For example, vitamin C helps to regenerate vitamin E, making it more readily available to protect the skin from free radicals. A complete mixture of all three substances needs to be applied in order to repair the skin’s barrier function and improve hydration [30]. This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent [56]. While there are a few acid treatments out there that also give you a low dose of niacinamide (like the COSRX AHA and BHA ), I do recommend using separate products if you want to see the best results. Exfoliation or Masking (Optional) This is a completely optional step (skip to number 3 or 4 if don’t … Products That Combine N-Acetyl Glucosamine & Niacinamide: We have discussed 12 examples of skincare ingredient combinations where less is not more. (1996). In addition, glycolic acid is very good at penetrating skin [47]. My other concern is can i use more of the same product in a skin care routine. ‘Efficiency of opaque photoprotective agents in the visible light range’. Before all that, you have to know where to start. Furthermore, niacinamide appears to have an additive effect when combined with NAG. Iron oxide is not an approved sunscreen but is often added to mineral sunscreens to reduce white cast. ‘Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color’. Products That Combine Centella Asiatica & Vitamin C: Products That Combine Centella Asiatica & Vitamin C & Glycolic Acid: As mentioned earlier, sunscreen is very very important for preventing aging and improving overall skin health. Let us know in the comments section! When vitamin C alone, as well as in combination with vitamins E and A, was combined with the centella asiatica extract, collagen production increased 3-fold (3x). ‘The effect of glycolic acid on the treatment of acne in Asian skin’. I’m using the salicylic acid cleanser from The Inkey List. The combination of the two completely got rid of my under-skin bumps and any other spots, The Niacinamide helps to balance my skin’s oil-production without completely stripping it, They work really quickly, you get visible results after just one or two uses, They’re so cheap (only around 10 euros each! Ceramides account for about 45-50% of this mixture, cholesterol for approximately 25%, and free fatty acids for around 10-15% [25]. Products That Combine Retinol & Niacinamide: Although the combination of glycolic acid and vitamin C may not be suitable for all skin types, they make a powerful pairing. The Ordinary Salicylic Acid 2% Solution is a direct acid. (1991). Zinc Oxide + Iron Oxide = Increased Photoprotection, Reduced Hyperpigmentation. Deciem has three skin care brands: Niod, Hylamide and The Ordinary, listed in decreasing order of luxuriousness and price. ‘Topical green tea polyphenols and caffeine as a treatment for acne vulgaris’. and then the Salicylic Acid directly on spots or spotty areas. Manela-Azulay, M. & Bagatin, E. (2009). Niacinamide & Retinol Together = A Perfect Pair! These two definitely address a certain skin type: the Niacinamide + Zinc is your best friend if you suffer from oily skin, and combined with the the Salicylic Acid it’s perfect to treat blemish- and acne-prone skin. Farage, M., Miller, K., Elsner, P. & Maibach, H. (2013). That would be a bit too harsh. But how do we know which skincare ingredients work well together? Haftek, M. Mac-Mary, S., Le Bitoux, M. et al. Kim, W. (2013). Lee, T., Seo, J., Baek, S. & Kim, S. (2014). http://theordinary.com/product/rdn-niacinamide-10pct-zinc-1pct-30ml?redir=1, http://theordinary.com/product/rdn-salicylic-acid-2pct-solution-30ml?redir=1. Ceramides account for about 45-50% of this mixture, cholesterol for approximately 25%, and free fatty acids for around 10-15%, When this lipid matrix is depleted, skin can become dehydrated. While all patients experienced reductions in hyperpigmentation, those who used the iron oxide sunscreen experiences significantly greater improvements, Murad City Skin Age Defense Broad-Spectrum SPF 50 PA++++, Skinceuticals UV Defense Broad-Spectrum SPF50 Physical Fusion Sunscreen, Tizo 3 Tinted Face Mineral SPF40 Sunscreen, Another great skincare ingredient combination for, Resveratrol is the potent antioxidant found in grapes (and red wine!) ‘Preliminary open-label clinical evaluation of the soothing and reepithelialisation properties of a novel topical formulation for rosacea’. ‘Interaction of vitamins C and E as better cosmeceuticals’. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67%, Some research suggests that iron oxide can increase the overall sun protection offered by zinc oxide sunscreens by absorbing all wavelengths of visible light, This is particularly relevant for individuals with hyperpigmentation and melasma as visible light can increase melanin production, In one study, individuals on a hydroquinone treatment regime were provided with a standard broad-spectrum SPF50 sunscreen or a similar sunscreen that also contained iron oxide and instructed to apply it every day. ‘Antioxidants and the skin: Understanding formulation and efficacy’. I've read several posts saying that niacinamide and salicylic acid shouldn't be used on the face at the same time, but I've also read about people who do just that and have had success with it. These effects are largely down to the polyphenols (antioxidant molecules) that are naturally present in green tea. For example, 2% NAG, alone, reduced the appearance of facial hyperpigmentation, but this reduction was far greater when 2% NAG was combined with 4% niacinamide. ‘Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo’. In some instances, this may lead to increased skin irritation, but this is not always the case. It inhibits tyrosinase, the key enzyme in the production of melanin, in various ways and thus prevents the conversion of DOPA to melanin [44]. Enlarged pores are caused by two main factors; increased sebum levels and reduced levels of collagen and elasticity in the skin. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. Should I keep using them at the same time, and if so, in what order? Lowe, N. (2006). (2011). Thank you. Layering and mixing skincare ingredients can be overwhelming at the best of times. I recommend you put on benzoyl peroxide in the morning and use salicylic acid and retinoids at night. Hydroxy acids are particularly useful for treating acne [1]. Hyaluronic acid and niacinamide are both water-based treatment and they can be used together. Furthermore, the retinaldehyde and glycolic acid formulation can enhance the effects of these other acne treatments, N-Acetyl Glucosamine (NAG) is an amino sugar and precursor to hyaluronic acid that inhibits tyrosinase glycosylation, thus reducing melanin production, However, NAG can be unstable when used alone, Research suggests that niacinamide can decrease the transfer of melanosomes from melanocytes to keratinocytes by up to 68% and interferes with the cell signalling pathways between keratinocytes and melanocytes. Laura is a skincare addict and sunscreen enthusiast with more than 10 years of experience working in healthcare and over 5 years of experience working as a nurse. (2008). ‘Epidermal desquamation’. In short, salicylic acid is beta hydroxy acid (BHA) that penetrates deep into the pores and exfoliates. After reading your article which i enjoyed. This suggests that the combination of zinc oxide and iron oxide in sunscreen is particularly beneficial for individuals with melasma. So will ingredient X counteract our ingredient Y? They are all skin care lines that focus on clinical formulas. & Berge, C. (2006). However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids) [30], with ceramide-dominant formulations being more suitable for some skin conditions [32]. ‘Cosmeceuticals vitamins’. Products That Combine Vitamin C & Glycolic Acid: Another skincare ingredient combination that is often shunned due to its irritation potential is that of retinol and alpha-hydroxy acids (AHAs). Per those acne-fighting benefits, niacinamide is often paired with salicylic acid, a beta-hydroxy acid that’s a mainstay in acne products, says Dr. Frieling. ‘Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial’. As the stratum corneum is the first to absorb the oxidative stress from free radicals produced by UV radiation, the levels of vitamin E in the skin are often depleted and regular topical application of vitamin E is recommended, Vitamin C and vitamin E are possibly the best example of a skincare power couple as they each enhance the effects of the other. Haywood, R., Wardman, P., Sanders, R. & Linge, C. (2003). Hello! Visit our online shop: https://shop.beautywithinofficial.com/ Hi guys! For example, in a study that incubated human skin for 48 hours with centella asiatica, vitamin A, vitamin E, vitamin C, and their combinations, each ingredient, alone, increased the production of collagen two-fold (2x). (2007). & Lupo, M. (2009). For example, vitamin C helps to regenerate vitamin E, making it more readily available to protect the skin from free radicals.

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